Aging of the placenta 32 weeks. Premature aging of the placenta: causes, symptoms, treatment. Causes of premature aging of the placenta

What you need to know about premature aging of the placenta

Premature aging of the placenta - Russian doctors scare many expectant mothers with this term. Why is this diagnosis so dangerous, on what basis is it made and how is the pathology treated?

The placenta, and among the people - "children's place", is an organ that is formed in a pregnant woman and functions until the birth of a child. It is thanks to the placenta that nutrients and oxygen can be delivered to the baby. And the development of the baby depends on the state of the placenta. If he does not have enough food, there is a high probability of a delay in his development, and in severe cases, even death.

How and why does the placenta age?

During pregnancy, the placenta changes and slowly develops its resource. Doctors know 4 degrees of placental maturity: 0,1,2,3. 0 - the placenta is in perfect order. Grade 3 usually happens for a period of 38 weeks or more. These degrees are determined by the doctor of ultrasound diagnostics. The structure of the placenta, its structure, thickness is taken into account. Premature maturation of the placenta is set at the slightest deviation from the norm.

Why is the "children's place" in some women quickly "aging"? Usually a whole range of problems is to blame for this. This is the uncontrolled intake of various medicines (including dietary supplements, vitamins), viral diseases (influenza, acute respiratory infections, acute respiratory viral infections, etc.), smoking, alcohol and drugs, etc. But more often, the causes of premature aging of the placenta remain unexplained .

What is dangerous pathology and what are its consequences

Perhaps we need to start with how this diagnosis is correctly made. Many doctors write it without reason. And the maturation of the "children's place" is considered accelerated if the degree of maturity for up to 32 weeks exceeds the second, or the doctor puts the third degree for a period of less than 36 weeks. And then, this “diagnosis” is not a diagnosis at all, but a moment that the doctor should pay attention to, and, most likely, conduct an additional examination. And this is an ultrasound with a study of fetal blood flow and cardiotocography (CTG). That is, premature aging of the placenta at 32, 33, 34 weeks is not a sentence at all, and often not even a reason for excitement. As for incorrect diagnoses, our Russian doctors are very fond of talking about this pathology, putting the first one instead of the zero degree of maturation for up to 30 weeks. It is not right. What consequences of premature aging of the placenta are still possible? It all depends on how bad the condition of the placenta was and what specific violations in the development of the child led to. Most often, this is the birth of children with low weight.

What to treat?

Unfortunately, it will not work to return the original state of the "children's place". Many mothers, having read about the dangers of premature aging of the placenta, ask their doctor to prescribe medications that will help the child get the missing nutrients and oxygen. But you need to try to do something only if there are signs of fetal suffering. And they are detected with dopplerography and CTG, ultrasound also assists in diagnosis, because it can be used to measure all parts of the child's body and say with a very high degree of probability whether he has a developmental delay. If yes, and it is more than 2 weeks, the woman will be admitted to the hospital for treatment. In severe situations, a caesarean section may be offered before the onset

The placenta is an important organ of a pregnant woman, which is formed and exists throughout the entire period of fetal growth. After the birth of a newborn, the child's place is rejected. This unique temporary organ connects mother and baby during pregnancy. It is thanks to the placenta that the baby receives the necessary nutrients.

A child's place, like any living organism, is formed, matures and ages. Each of these physiological processes must occur at its own time. In this case, the pregnancy will proceed successfully, and the child will be healthy. If the expectant mother wants to know what, for example, should be the degree of maturity of the placenta at 33 weeks of pregnancy, she should use a special table with standard indicators. Such a scheme will be given in the article below. Thanks to her, you can find out if the children's place is developing correctly.

When is the placenta formed?

The word placenta in Latin means "cake". This organ was named so due to its disc-shaped flattened shape.

Around the tenth day after conception, the cells whose purpose is to provide a connection between mother and fetus begin to actively divide. As a result, special enzymes are produced. Their task is to create favorable conditions in the uterine cavity for the subsequent possibility of saturating the child with nutrients from the mother's body. After that, a constant blood exchange is formed between the pregnant woman and the baby. The growth of the placenta becomes so active that the size of this organ in the initial stages even exceeds the size of the embryo.

Further, there is a constant increase in mass and growth of the villous tree of the children's place. The branching of blood vessels continues due to the division of each of their processes into several new ones. Such a temporary organ completes the growth process almost before the very birth. The correctness of the development of a child's place is characterized by such an indicator as a table with a corresponding description of the characteristics will be presented below.

What is the placenta for?

The main task of the placenta is to ensure the vital activity of the fetus during the entire period of pregnancy. The children's place performs the following important functions:

• provides immunological protection of the fetus, passing the necessary antibodies of a pregnant woman to the baby, but at the same time retains certain cells of the mother's immune system that could trigger the mechanism of rejection of the embryo, mistaking it for a foreign object;
• removes toxins;
• protects the baby from the negative influence of the environment, the harmful effects of bacteria and viruses;
• performs the functions of an endocrine gland, synthesizing certain hormones that are necessary for a successful pregnancy;
• supplies the fetus with oxygen and removes the resulting carbon dioxide;
• delivers nutrients to the child and helps to get rid of waste products.

The condition of the placenta has an extremely important impact on the condition of the baby and on the process of pregnancy as a whole. To maintain the health of this organ, it is necessary to protect it from the harmful effects of a different nature. For example, it is recommended to avoid crowds of a large number of people, because even banal SARS or acute respiratory infections can be dangerous. The mother-to-be should not smoke. If a woman has sexual infections, they need to be disposed of.

Normative thickness of the placenta

From the very beginning of pregnancy, the placenta actively grows and develops. By 16-18 weeks, this organ becomes fully functional. The thickness of the child's seat increases slightly from day to day. This indicator reaches its maximum by 34 weeks. If the pregnancy proceeds safely, then after another couple of weeks, the growth and increase in the thickness of the placenta stop, and sometimes even decline.

This indicator, which characterizes the state of the child's place, can be determined exclusively by ultrasound diagnostics. The section with the greatest thickness should be measured.

If the thickness of the child's place at a particular stage of pregnancy does not correspond to the normative indicators, then the functioning of this organ is impaired. In this case, the child may also suffer.

Another indicator by which you can assess the state of the child's place is the degree of maturity of the placenta by weeks. A table with standard values ​​will help to correctly assess the situation. And now we will consider cases when the thickness of the children's seat differs from the standard.

If the thickness of the placenta is more than normal

Anemia, preeclampsia, Rhesus conflict, diabetes mellitus can be the cause of excessive in a pregnant woman. Infectious diseases also have a negative impact on the state of the child's place. Moreover, the danger exists even in the case when the expectant mother is simply a carrier of bacteria. If a pregnant woman smokes, uses alcohol or drugs, then the thickness of her placenta can also be increased.

The rate of aging of a child's place with such a pathology is accelerated, which means that this organ does not cope with its functions effectively enough. If the placenta is thickened, it swells, the structure of its walls becomes different, and a hormonal imbalance occurs. The result of such changes is insufficient provision of the child with oxygen and nutrients. This can cause a delay in the baby, hypoxia, premature birth, or even death of the fetus.

Based on the results of ultrasound diagnostics, dopplerography or cardiotocography, the doctor prescribes drugs to a pregnant woman with a thickened baby's place that stimulate uteroplacental exchange and support the normal development of the baby. If the condition of the fetus does not inspire concern, the doctor may limit himself to closer monitoring of the expectant mother.

If less than normal

A thin placenta may indicate hypoplasia of the child's place. This is the name of the state when this organ is not sufficiently developed and is not able to effectively cope with its functions.

An excessive decrease in the thickness of the placenta can be both a feature of the constitution of a pregnant woman (most often this happens in women of medium build), and be the result of a number of other reasons. For example, such a pathology can occur after the expectant mother has suffered an infectious disease. Hypertension, hemolytic disease or atherosclerosis may also affect.

If the insufficient thickness of the placenta is a consequence of any disease of the expectant mother, an increase in this indicator can be influenced by curing the corresponding disease. In other cases, the doctor uses drug therapy aimed at minimizing the possible negative consequences of the child's development.

It is time to consider such an important indicator as the maturity of the placenta.

What is the maturity of the placenta?

The maturation of the placenta is a natural process that accompanies the growth of this organ. The development of the child's place occurs in such a way that it can fully and timely meet the needs of the fetus.

The degree of maturity of the child's place is the most important indicator. With its help, you can assess the state of the placental complex. Also, this characteristic helps to identify pathological changes in the structure of the child's place in time, which can have a negative impact on the fetus.

If the pregnancy proceeds normally, then during its period the placenta passes 4 degrees of maturity. A detailed description of each of them follows below.

The degree of maturity of the placenta by weeks (table)

There are 4 degrees of maturity of the child's place. Each of them corresponds to a certain period of development of this organ.

Below is a summary diagram describing each degree of placental maturity by week. The table contains characteristics of the structure of the child's place and chorionic tissue at various stages of pregnancy.

The degree of maturity of the placenta	Normal gestational age	Structure of the placenta	Characteristics of the chorionic tissue adjacent to the fetus	Presence of calcium deposits
	By 30 weeks	Homogeneous	Smooth and even	Virtually absent
	Weeks 27 to 36	There are few seals	Isolated echogenic inclusions are present. The chorionic plate becomes waviness	Available in small quantities
	34 to 39 weeks	In large numbers there are pronounced seals	There are small echogenic inclusions in large numbers. The chorionic plate becomes even more waviness	There are clearly visible areas
	After 36 weeks	May have cysts	The waviness of the chorionic plate is pronounced. The placenta has a lobular structure	Available in large quantities

The table shows that the zero degree of placental maturity at 30 weeks is an indicator that is within the normal range. If the doctor, after examining the expectant mother, assessed the maturation of the child's place in this way, then the pregnancy is proceeding well.

A detailed description of each of the degrees of maturity of the placenta

The next stage of maturation of the placenta normally lasts from 27 to 36 weeks of pregnancy. During this period, the size of the child's place stops growing, but its thickness gradually increases. The first degree of placental maturity at 34 weeks is a good indicator. Although at such a time after visiting the doctor, there is an opportunity to find out that the maturation of the child's place has reached the second level. And this will also be the norm.

From 34 weeks, the most calm and stable stage of growing up in a child's place begins. The second degree of maturity of the placenta at 39 weeks is a boundary indicator. After this period, the development of a temporary organ should move to the third level. If such a transition occurs before the specified time, you should not worry. Most often, there is no cause for alarm in this case.

Then comes the third degree of maturity of the placenta. At 36 weeks and later, the baby's place enters the final phase of its development. During this period, the biological aging of the temporary organ occurs. It is accompanied by a reduction in the exchange area of ​​the placenta and the appearance of a large number of areas of calcium deposits.

If the child's place is ahead of the norm of its development or, conversely, lags behind it, the development of pathologies is possible. Such situations are discussed below.

Untimely development of the placenta

One of the problems associated with a child's place can be its premature maturation. We can talk about such a pathology if the 2nd degree of placental maturity at the 32nd week of pregnancy has already begun. In this case, the condition of the fetus must be carefully monitored. After all, this situation indicates placental insufficiency. This common case will be discussed in more detail below.

Another problem, which is somewhat less common than the previous one, is the late maturation of the child's place. Most often, such a pathology is characteristic in the case when there are congenital malformations of the fetus. Additional risk factors are the disease of the future mother with diabetes mellitus, Rhesus conflict, or the presence of such bad habits in a pregnant woman as smoking or drinking alcohol. If there is a delay in the maturation of the placenta, then the risk of stillbirth increases.

Premature maturation of the placenta

Such development is considered premature when the second degree of placental maturity occurs at and before.

The causes of this pathology are as follows:

• preeclampsia;
• disturbed hormonal background;
• diseases of the cardiovascular system or diabetes in a pregnant woman;
• the presence of pathogens of infectious diseases;
• hypertension in the expectant mother;
• multiple pregnancy;
• excess calcium in the body of a woman;
• placenta previa or abruption;
• Rhesus conflict;
• the use of pregnant alcohol, nicotine, narcotic substances.

Growing up is also considered premature when the third degree of placental maturity occurs before 36 weeks of pregnancy. However, in itself, early aging of a child's place is not an immediate threat to the health or life of the fetus. Such a pathology is dangerous in the case when the doctor, after examining the pregnant woman, revealed violations that could lead to negative consequences. It may be his intrauterine growth retardation, the risk of premature birth.

Doctors should verify the presence of pathology using other diagnostic methods. If the fears are confirmed, then the pregnant woman is prescribed appropriate treatment, in some cases even inpatient treatment.

Conclusion

The most important indicator of the state of the placenta is the degree of its maturity. This characteristic makes it possible to evaluate both physiological and pathological changes in the temporary organ. Using the special table given in the article, the expectant mother can find out the appropriate degree of placental maturity for a specific gestational age. 31 weeks, for example, should be characterized by the first level of development of the child's place.

If the diagnostic results are only slightly different from the normative indicators, there is no need to worry. Trust your doctor. He will conduct additional studies, assess the condition of the fetus and, if necessary, prescribe appropriate treatment.

The placenta is an important organ that provides the fetus with nutrients and protects against most harmful agents.

The formation of the placenta (children's place) begins from the moment of penetration of the chorionic villi into the endometrium (approximately 3-4 weeks of pregnancy).

Further, the active growth of tissues and the vascular bed begins, a full-fledged placenta is formed. And then the reverse process takes place: deformation and blockage of blood vessels, the death of tissue fragments, which is called "aging of the placenta."

If for some reason the placenta ages before the fetal maturation, the diagnosis is “premature aging of the placenta”.

Doctors make a decision depending on the duration of pregnancy and the readiness of the unborn baby: premature birth, or carrying out pregnancy on an outpatient basis or under round-the-clock supervision of doctors in a hospital.

During pregnancy, the placenta goes through several stages of development.

During the first trimester, the placenta grows and develops, and from 10-12 weeks it is already formed and begins to fulfill its protective functions.

It is with the activity of the placenta that the weakening at the end of the first trimester is associated.

By the end of pregnancy, tissue cells and blood vessels of the child's place are gradually deformed and die, this process is called "placental aging".

This usually happens by 37-38 weeks, when all the organs and systems of the fetus have matured. But it happens that the placenta begins to die at an earlier date. This is the reason for the hospitalization of a woman. Pregnancy can be saved with medication.

The most reliable method for diagnosing the maturity of the placenta is ultrasound and Dopplerography (blood flow measurement).

In accordance with the ultrasound data, the specialist’s conclusion will indicate the degree of maturity of the placenta, it is classified as follows:

• 0 degree.

Normally, the zero degree persists until about 30 weeks.

This is a period of active work of the placenta, freshly formed tissues reliably protect the baby from harmful external toxins, metabolic products are effectively filtered (they are excreted by the mother's excretory system).

The blood supply to the vessels is good, the fetus receives the necessary nutrients.

• 1 degree

The first degree of placental maturity is observed from about 27 to 34 weeks. Continued active growth of the placenta, at this stage it reaches its final size.

• 2 degree.

It falls on 34-38 weeks. It is characterized by the normal functioning of the mature placenta. By the end of the term, some vascular changes are possible, but they do not have a significant effect on blood flow. The surface of the placenta becomes more dense and bumpy.

• 3 degree.

The placenta reaches its maximum maturity in the last weeks of pregnancy (37-40).

This period is associated with the natural wear and tear of tissues and blood vessels. There are signs of salt deposition and changes in blood flow.

But if examinations show that the fetus has a normal heart rate, growth and physical activity correspond to the gestational age, then you should not worry.

If the changes are diagnosed at earlier stages (for example, maturation to stage 1 before 30 weeks or a sharp transition to stage 3 with fetal growth retardation), they speak of premature aging of the placenta.

If chronic diseases of the mother are a contraindication to taking any of these drugs, the obstetrician-gynecologist, together with a specialized specialist, will select an individual therapy that is safe for the expectant mother and baby;

• Taking vitamins.

Vitamins A, and C, they will provide antioxidant protection and normalize the transport function of the placenta;

• Decreased tone of the uterus.

The decrease also improves placental blood supply. For this purpose, Ginipral is usually used in obstetric practice (if the mother has no contraindications!)

In the case of placental aging at an early stage (for example, the transition to stage 1 before 30 weeks), as a result of a set of measures taken, compensatory restoration of blood vessels is possible.

And in the future, pregnancy will develop according to the timing. After the control examination ( and ), the woman is discharged under observation at home.

The frightening diagnosis of "premature aging of the placenta" may be the result of bad habits, an untreated infection, or chronic diseases of the mother. Most causes are treatable or correctable.

Supportive care in a hospital setting will help restore blood flow and provide the fetus with conditions for normal further development.

The placenta is a special organ that arises and grows in the uterine cavity during pregnancy, the main task of which is the correct connection of the blood supply systems of the fetus and matter. In the body of the placenta, biochemical processes are performed that are responsible for the normal development of pregnancy, for the production of special hormones that provide the fetus with oxygen, and also protect it from the influence of harmful factors. After the birth of a child, the child's place dies off and separates 30-50 minutes after birth.

The degree of maturity of the placenta at different stages of pregnancy

Like any organ, the placenta has its own "age", that is, it is born, develops and matures, and then ages and after childbirth - dies. This is a normal physiological process, however, early, premature maturation or aging of the placenta poses a threat to the health and life of the baby.

Currently, in obstetric and gynecological practice, four stages of placental maturation are differentiated, and each of them normally corresponds to a certain period of pregnancy.

However, there are so-called transitional stages, when signs of adjacent degrees of maturity may appear, which is associated with a different rate of development of the fetus and placenta, which is carried out from its marginal sections to the center.

• 0 - zero degree of maturity (according to the classification of Grannum P.A. 1979) can be diagnosed up to the 30th week;
• 0 - I degree (transitional period) is typical for 29, 30 weeks;
• I - the first degree of maturity is observed at 30 - 32 weeks;
• I - II (transitional period) is diagnosed at 32 - 34 weeks;
• II - the second degree of maturity corresponds to 34 - 40 weeks;
• II - III (transitional period) can last from 35 to 40;
• III - the third degree of maturity is diagnosed at 37 - 38 weeks to 40.

With the correct course of pregnancy, the growth of the placenta is completed by 36-37 weeks. After that, the thickness of the body of the child's place decreases or no longer changes. The ultrasound method of research (ultrasound) allows you to determine the thickness of the child's place and the degree of its development, which is directly related to the state of the chorionic membrane (the chorionic membrane surrounding the fetus and lining the fruiting surface of the placenta), the parenchyma (the villous outer fetal membrane of the embryo) and the basal layer (connective tissue lining of the uterus).

Changes in the structure of the placenta at different stages of pregnancy

At 0 degree of development of the placenta, its structure is homogeneous. The chorionic membrane is flat and smooth, without undulations. The basal layer is not defined.

If the zero degree of maturity changes to degree I before reaching the 27th week, this indicates the premature development of the placenta. As a rule, this condition occurs in the presence of negative factors: viral diseases such as rubella, chickenpox, suffered during pregnancy, smoking, drinking alcohol and drugs.

During the first degree At maturity, placental growth stops, and the body of the placental substance becomes thicker, and individual hyperechoic zones can be found in it, which are clearly visible on ultrasound, the chorionic plate becomes uneven. If at this time the doctor sets the II degree of maturity, this may be a sign of possible developmental disorders. In this case, it is required to take medications that activate blood flow in the vessels of the child's place.

At the II degree of maturity (35-39 weeks), during ultrasound, multiple echo-positive small inclusions are observed, the roughness of the chorionic plate increases, but its depressions do not reach the basal layer. In the basal layer itself there are small echogenic zones located linearly (the so-called basal “dotted line”). This stage of pregnancy is the most calm and stable. And even if in the middle of this period a III degree of maturity is determined in a pregnant woman, this does not often become a cause for alarm.

Grade III is usually observed at 37-38 weeks, when the placenta reaches the final phase in its development and corresponds to the duration of a normal full-term pregnancy. This period is characterized by biological aging of the placenta, the structure of which becomes lobar, and the depressions of the chorionic membrane reach the basal layer. This stage requires a detailed analysis of any inconsistencies observed in the body of the placenta, since even minor deviations from normal development can be signs of threatening complications. If the diagnosis at the III degree of development indicates fetal hypoxia, then the management of childbirth is often recommended, with the use of surgical intervention (caesarean section).

Premature aging of the placenta

Premature aging of the placenta is ascertained in cases where the II degree manifests itself before 32 weeks, and III - before 36 weeks. This is not yet evidence of the pathology of pregnancy, but requires mandatory control of the movement of blood in the vessels of the uterus and the child's place.

In the case of premature maturation of the child's place, a special protein settles on the villi, which is released from the blood circulating between them, and prevents their participation in the metabolic processes of the uterine and placental blood flow. At this stage, by the end of 39-40 weeks, a decrease in the thickness of the placental membrane from 25 to 6 microns is recorded. In the tissues of the placenta, dystrophic changes are observed, lime salts are deposited in certain areas.

If the degree of maturation does not correspond to the gestational age, for example, when it should be I according to the weeks of pregnancy, but they state II, or at the 33rd week they find the III degree, then a natural question arises: What is the danger?

The placenta, as one of the most important links in a single biological system that unites the fetus, the umbilical cord and the mother's body, works on many life problems:

• Provides oxygen to fetal tissue cells and removes carbon dioxide from the blood;
• Delivers nutrients to cells and removes metabolic products;
• It is a barrier and a filter that protects the embryo from the negative effects of harmful substances that enter the mother's body: drugs, toxins, bacteria;
• Produces hormones necessary for the proper development of pregnancy.

Therefore, premature aging or death of areas of the child's place negatively affects these functions. Deterioration of blood flow in the vessels of the uterine-placental system with a discrepancy between the maturity of the placenta and the established weeks of pregnancy is dangerous for the development of placental insufficiency, leading to hypoxia and fetal hypotrophy, and in the worst case, intrauterine death.

Causes of premature aging of the placenta.

The most common reasons:

1. Nicotine, alcohol and narcotic substances that poison the cells of a child's place.
2. Diabetes mellitus, thyroid disease.
3. Hypertension in pregnancy.
4. Late toxicosis (gestosis).
5. Negative rhesus blood in the mother.
6. Previa and early detachment of the placenta.
7. Multiple pregnancy.
8. endocrine disorders.
9. Multiple pregnancy.
10. intrauterine infections.

Late maturation of the placenta, causes and consequences

Such a diagnosis in the practice of pregnancy and childbirth is less common than the definition of premature maturation of the placenta. The main reasons for this status of a children's place are:

• primary and secondary diabetes mellitus in a pregnant woman;
• negative Rh factor leading to Rh conflict;
• chronic diseases of the expectant mother;
• smoking during pregnancy;
• alcohol consumption;
• fetal malformations.

With a delay in the development of the placenta and its late maturation, we can say that it does not fulfill its mandatory functions - providing the baby with oxygen and the nutrients necessary for its proper development. In addition, carbon dioxide and metabolic products are retained in the body of the fetus, which contributes to its intoxication and leads to developmental delays.

The prognosis for the established diagnosis of "late maturation of the placenta" in most cases is unfavorable without qualified medical treatment in a hospital setting. Otherwise, there is a high risk of stillbirth and mental retardation in the fetus.

Thus, the maturation of the placenta, its development, aging and death are natural processes, but the syndrome of premature aging and late maturation requires special attention. Modern methods for studying blood flow in the fetal-placental system have shown that an extended analysis of its circulation allows the attending physician to make an accurate diagnosis.

And this makes it possible to prescribe the most effective treatment, choosing the optimal tactics for managing pregnancy and obstetrics in order to achieve their favorable completion and the birth of a healthy child.

The placenta is formed during pregnancy. It is on her that the production of hormones, a sufficient supply of oxygen to the fetus, and nutrients depends. There is a certain scheme for the maturation of the placenta, which was laid down by nature. Premature aging of the placenta has negative consequences for the health of the fetus and the expectant mother.

Premature maturation of the placenta

The placenta provides the functions of nourishing the blood circulation and respiration of the child. In a baby, these processes cannot occur on their own until all organs are formed. The functions of respiration and nutrition occur with the support of the mother. The placenta provides protection for the baby from various infections.

The placenta, like other organs in our body, ages and is preparing to leave the body by the 37th week of pregnancy.

But often with a woman's frivolous attitude to her health during pregnancy, the placenta matures early. The development of this organ ahead of time is a pathology, and entails various consequences. If the placenta begins to mature a little ahead of schedule, this does not mean that the situation is critical. This may be due to the characteristics of the woman's body. If the placenta matures before 36 weeks, this indicates early maturation, which must be stopped.

Accelerated maturation of the placenta threatens:

• lack of oxygen;
• Nutrient deficiencies;
• Detachment of the placenta;
• Termination of pregnancy is not ruled out.

Insufficient supply of oxygen and nutrients often leads to low weight of the child, hypoxia. A prematurely aging placenta can lead to the birth of a child with brain pathologies, to damage to the organs of the mother or child. It happens that leads to death. To prevent such consequences, it is necessary to stop the premature maturation of the placenta in time.

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